Urine Proteomics to Detect Biomarkers for Chronic Allograft Dysfunction
نویسندگان
چکیده
منابع مشابه
Urine proteomics to detect biomarkers for chronic allograft dysfunction.
Despite optimal immunosuppressive therapy, more than 50% of kidney transplants fail because of chronic allograft dysfunction. A noninvasive means to diagnose chronic allograft dysfunction may allow earlier interventions that could improve graft half-life. In this proof-of-concept study, we used mass spectrometry to analyze differences in the urinary polypeptide patterns of 32 patients with chro...
متن کاملChronic renal allograft dysfunction.
The major causes of renal transplant loss are death from vascular, malignant or infectious disease, and loss of the allograft from chronic renal dysfunction associated with the development of graft fibrosis and glomerulosclerosis. Chronic allograft nephropathy (CAN) is the histologic description of the fibrosis, vascular and glomerular damage occurring in renal allografts. Clinical programs rel...
متن کاملUrine Proteomics and Biomarkers in Renal Disease
The application of urine proteomics is a useful approach to the study of the proteins involved in healthy and diseased kidneys and may provide a noninvasive approach to assess disease activity and to monitor clinical response in patients with renal diseases. This technique may provide an additional tool in clinical trials and for the assessment of prognosis for patients. Both soluble proteins a...
متن کاملProteomics and bioinformatics approaches for identification of serum biomarkers to detect breast cancer.
BACKGROUND Surface-enhanced laser desorption/ionization (SELDI) is an affinity-based mass spectrometric method in which proteins of interest are selectively adsorbed to a chemically modified surface on a biochip, whereas impurities are removed by washing with buffer. This technology allows sensitive and high-throughput protein profiling of complex biological specimens. METHODS We screened for...
متن کاملChronic lung allograft dysfunction: evolving practice.
PURPOSE OF REVIEW Chronic lung allograft dysfunction (CLAD) was recently introduced as an overarching term covering different phenotypes of chronic allograft dysfunction, including obstructive CLAD (bronchiolitis obliterans syndrome), restrictive CLAD (restrictive allograft syndrome) and graft dysfunction due to causes not related to chronic rejection. In the present review, we will highlight t...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2008
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2007101137